SLU-PP 332 (Capsules)

SLU-PP-332 is an exercise mimetic compound that targets estrogenrelated

receptors acting as a potent agonist for ERRα, ERRβ, and ERRγ. In

animal studies, it demonstrates benefits similar to regular exercise,

including increased energy expenditure, enhanced fatty acid oxidation,

reduced fat mass, and improved insulin sensitivity, suggesting potential for

treating metabolic diseases like obesity and diabetes. The compound

works by activating a natural metabolic pathway in the body to boost

metabolism and has shown promise in mouse models for weight loss and

increased exercise endurance.

How it works and potential benefits:

• ERR Agonist: SLU-PP-332 functions by activating estrogen-related receptors,

primarily ERRα.

Exercise Mimicry: It triggers an exercise-like response in the body, specifically

in muscles, by increasing mitochondrial respiration and oxidative fibers.

• Metabolic Benefits: This activation leads to increased energy expenditure and

improved fat metabolism, even without physical activity.

• Obese mice treated with SLU-PP-332 showed a decrease in body weight and fat

mass.

• The compound improved insulin sensitivity and reduced blood glucose levels.

• May improve running endurance, increased grip strength, and greater running

distances.

• SLU-PP-332 also demonstrated protective effects against age-related kidney

dysfunction in mice.

Potential Applications

• Obesity and Metabolic Syndrome: SLU-PP-332 shows potential as a therapeutic

agent for conditions like obesity and metabolic syndrome.

• Age-Related Muscle Loss: It could also be beneficial for treating age-related

muscle loss.